GNE-7883 (GNE7883) is a potent, reversible, allosteric inhibitor of the YAP1-TEAD interaction.
The potent inhibition of pan-TEAD lipidation with GNE-7883 translated well to the disruption of YAP1 binding to each of the four TEAD isoforms by the YAP1 HTRF assay.
Product Info
Cas No.
2648450-42-2
Solubility
DMSO : 125 mg/mL (279.06 mM; ultrasonic and warming and heat to 60°C)
Appearance
Solid powder.Please contact us for more accurate information.
Shipping and Storage
Store Temp
Room temperature in continental US; may vary elsewhere.
Ship Temp
Powder:3 years -20°C。In solvent:1 years -80°C
References
1. Jeffrey K Holden, et al. Cell Rep. 2020 Jun 23;31(12):107809.
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