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CC-90009

Product ID: TAC02233

Cas No. : 1860875-51-9

Purity: 98%+

Product Unit Size	Stock	Prize
10mg	In stock	＄133.33
25mg	In stock	＄300.00
50mg	In stock	＄466.67
100mg	In stock	＄633.33
Bulk Size	Bulk Discount

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COA HNMR HPLC

Description Product Info Shipping and Storage References

Description

Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4^CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation^[1]^[2].

Product Info

Cas No.	1860875-51-9
Formula	C₂₂H₁₈ClF₂N₃O₄
Formula Wt.	461.85
Synonym	Cereblon modulator 1;BCP33889;CC90009; CC 90009; Cereblon modulator 1;2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
Solubility	DMSO : 125 mg/mL (279.06 mM; ultrasonic and warming and heat to 60°C)
Appearance	Solid powder.Please contact us for more accurate information.

Shipping and Storage

Store Temp	Room temperature in continental US; may vary elsewhere.
Ship Temp	Powder：3 years -20°C。In solvent：1 years -80°C

References

[1]. Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677. [Content Brief]

[2]. Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 Feb 25;64(4):1835-1843. [Content Brief]

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