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GDC-6036

Product ID: TAC00006

Cas No. : 2417987-45-0

Purity: 98%+

Product Unit Size	Stock	Prize
5mg	In stock	＄833.33
25mg	In stock	＄1666.67
100mg	In stock	inquiry
500mg	In stock	inquiry
Bulk Size	Bulk Discount

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COA HNMR HPLC

Description Product Info Shipping and Storage References

Description

Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC₅₀ of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.

Product Info

Cas No.	2417987-45-0
Formula	C₂₉H₃₂ClF₄N₇O₂
Formula Wt.	622.06
Synonym	1-((S)-4-((R)-7-(6-Amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)prop-2-en-1-one
Appearance	Solid powder.Please contact us for more accurate information.

Shipping and Storage

Store Temp	Room temperature in continental US; may vary elsewhere.
Ship Temp	Powder：3 years -20°C。In solvent：1 years -80°C

References

[1]. Lingyao Meng, et al. Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach. Anal Chem. 2022 Sep 20;94(37):12927-12933. [Content Brief]

[2]. Sushant Malhotra, et al. Fused ring compounds. WO2020097537A2.

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